Cyphostemma juttae is a very sought-after plant for the garden, as are other caudiciform plants such as baobabs, adeniums and tylecodons. They make superb container or open garden subjects in and around the garden, especially around swimming pools and courtyards. Because this species grows mainly in the summer, plants must be kept dry during the colder winter months. They are ideal accent plants for a rockery, or may be planted in a large container on a sunny protected patio.

The tree grape fares best in a loamy or sandy soil where drainage is optimal. Adding plenty of river sand and general compost will greatly improve drainage in heavy clay soils. Soil quality can also be improved dramatically by lightly working some bone meal into the soil. Although smelly, the effect on soils is quite remarkable. As a rule of thumb, use only organic products, such as those based on seaweed extract, especially if plants are going to be fed on a regular basis. Organic products won't burn or damage plants.

As with all succulents, one must be careful not to over-water. These plants can survive with very little water, and too often plants die as a result of excessive water. If one lives in a very wet area, it is preferable to keep plants in large containers where they can be easily moved to a sheltered place. This also helps where severe frost occurs as cyphostemmas are not completely resistant to frost.

The seeds of Cyphostemma juttae can be sown in winter (June to August). Although they take a considerable time to germinate, success is almost guaranteed. Propagation can also be undertaken by means of cuttings. Cuttings or truncheons can be rooted in coarse river sand. Again it is important to water with caution, especially after the cuttings have rooted.