It is possible to propagate Serruria florida from seed and cuttings; however, seed is difficult and vegetative propagation is recommended.

Tip, stem and heel cuttings are taken during late summer. Apply rooting hormone to semi-hardwood cuttings. Place in a propagation soil mixture of 50% milled pine bark and 50% polystyrene granules. Good rooting of the plant will take place if the propagation greenhouse has good misting and under-bench heating. Rooting will take place within four weeks. Rooted cuttings are removed from the mist bench and hardened off for four weeks. The hardened off cuttings are then potted in a soil medium made up of a suitable well-drained soil mixture consisting of composted pine bark, acidic river sand in equal parts loam/topsoil.

Seed is collected from the mature flower head. Sow in autumn. Treat with a fungicide that prevents pre- and post-emergence damping off. The effects of higher day temperatures and cooler night temperatures play an important role in initiating germination. The seeds can also be exposed to short periods of high temperatures followed by cooling water, which mimics the autumn temperatures and stimulates the seed to germinate. The young seedling should be grown in an area that is well ventilated and fairly well lit. The plants should be watered in the mornings and may be fed with an organic-based fertilizer. The young plants can be planted out in autumn or in the cooler months before the onset of summer. This will allow the root system to become established and gives the young plant a good chance of survival.

As an ornamental garden subject, S. florida makes a wonderful addition to a fynbos garden and is well complemented with Restio, buchu, Erica and Protea species. It makes an exquisite mid- to fore-layer planting. It is a water-wise plant and requires a well-drained, sunny position.

A root pathogen, Phytophthora, is detrimental to Proteaceae. Symptoms include the plant looking wilted and dry, followed by yellowing and death. As these symptoms are only seen once the fungus has damaged the plant, the best course of action is to remove the infected plant and burn it. Thereafter, sterilize the affected soil with a contact fungicide and refrain from replanting Proteaceae in that area. Good general plant hygiene and healthy vigorous mother stock will increase the potential of younger plants to remain healthy.