Similar to that of other species in the Rutaceae family, Adenandra fragrans can be propagated by seed or by cuttings. For propagation by seed, first prepare a well-drained soil made of a mixture of sand, loam and compost in equal proportions. Place the mixture in deep trays with enough holes for drainage. Level the soil and water. Sow the seeds in autumn, sow in the trays and cover with about 3 mm of soil. A smoke treatment can be used to improve germination. Place the trays in an area with good air circulation and light. Make sure the trays remain damp. Seeds will take up to two months to germinate.

For propagation by cuttings, make sure the cutting is at least 50 mm long and taken from the current year’s growth. The best time to take a cutting is between six to nine weeks after the plant has flowered. When cutting the plant, make sure to make a clean cut below a node and remove most of the leaves on the bottom half of the cutting. The cutting can then be dipped in a rooting hormone. The cutting must then be placed in trays in a mixture of bark and polystyrene in equal proportions. The trays must then be placed in a misting unit or enclosed in transparent plastic to create a terrarium to increase humidity. Make sure the plastic does not touch the leaves and make sure that the mixture is always damp. Rooting will occur in up to 11 weeks. Rooted cuttings can then be placed in bags with a potting mixture of well-drained humus-rich fynbos soil. After three weeks the plants can be placed in the sun. Plants can be planted in the garden after seven to eight months.

Adenandra fragrans is best suited to fynbos gardens and can be planted in beds and rock garden pockets, in slightly acidic, well-drained soil enriched with compost, in full sun. For best effect they should be planted in groups of three or five with spacing of at least 200 mm between each plant. Planting them in groups also helps retain soil moisture. Mulching should take place one a year to help to suppress weeds, reduce water loss and keep the temperature of the soil low. They should be watered moderately. Light pruning of the branches can be done after flowering to maintain a compact growth and prevent the plant from becoming too woody.

Adenandra fragrans possibly has similar pests and diseases as other species in the Rutaceae family such as the citrus caterpillar, that can be controlled with pesticides. The fungus Phytophthora cinnamomii can be controlled by treating young plants with acylalanine and reducing the temperature of the soil by using mulch.