Adenium multiflorum grows well in warm, well-drained situations where the soil is sandy. In the garden they are not plants for cold or damp areas. They are ideal subjects for a dry rockery, giving a warm colourful display of bright flowers in winter. As container plants they may be kept in cooler places, but do not water them when they are dormant and protect the plants against frost.

Plants grow vigorously from seed, but rarely flower until they are four to five years old. This taxon is seen in cultivation, but is a distant second to A. obesum in availability, mainly because of its slower growth rate and shorter blooming season. At the Shingwedzi Camp in the Kruger National Park some exceptional specimens can be seen.

Water the plants well during hot weather. Keep the potting mix wet in temperatures of 30º C. Plants require high light intensity and temperatures of around 30º C, hot weather preferably accompanied by moderate to high humidity. Plants respond well to regular and generous fertilizing. Add slow-release fertilizer and micronutrients to potting mediums. Inadequate watering and feeding are the primary causes of  slow growth in adeniums.

Adeniums must be grown in containers in climates with frost or cool, wet winters. Dormancy can be detected when water consumption declines or when the leaves suddenly turn yellow. Watering should be drastically reduced and stopped when the plants are in full dormancy. Expanding terminal buds signal the end of dormancy and watering can then be increased. Plants need ample root space for rapid growth. The growth of root-bound plants is greatly inhibited and plants should be re-potted until they reach the desired size. The potting mix must provide excellent drainage and aeration. Over-watering and fertilization combined with inadequate light or poor air movement may lead to weak, elongated growth. Adeniums are surprisingly adaptable to cultivation and this adaptatbility includes adjusting their growth cycles to match the reversed seasons in the northern hemisphere (Rowley 1999). Care should be taken to avoid damage to the fleshy, brittle roots when repotting.

Propagation is by seed (the only means in the wild) and vegetative propagation by cuttings or grafting. Larger plants can be obtained from nurseries. Cuttings should preferably be tip-cuttings dipped in a rooting hormone and stuck into a coarse rooting medium and kept well watered. Grafting is also an effective method and more reliable than cuttings. Growing plants from seed is easy and seeds germinate in about a week at 30º C. Treating seeds with a fungicide before sowing reduces loss. Seedlings usually grow through the first winter before obligate dormancy appears.

Adenium multiflorum is susceptible to root rot when watered too frequently during cool weather or if chronically water-logged at any time. The use of a well-drained potting medium will prevent most problems with rotting. Pests rarely damage adeniums grown outdoors .Indoors or in containers, mealy bugs, spider mites, aphids and whiteflies often infest plants. Use pesticides carefully as adeniumsare sensitive to some.