Aloe ecklonis, can be propagated through several methods. The most reliable approach is removing offsets that develop around the base of the parent plant. When these offsets reach about one-third the size of the parent, they can be carefully separated, allowed to dry for a few days, and then planted in well-drained soil. Seed propagation is another option, involving collecting seeds from mature capsules and sowing them in a warm, slightly moist, free-draining soil mix, with germination typically occurring within 2-4 weeks. Leaf cuttings can also be attempted by cutting a healthy leaf at the base, allowing it to callus, and then planting it in slightly moist, well-drained soil. Regardless of the method chosen, providing proper care and suitable growing conditions is crucial for successful propagation.

Aloe ecklonis is easy to grow and adaptable. Grow it in a sunny position, in well-drained soil. It will do well on a well-watered site, or one that gets moderate water in summer, and will survive a dry winter. It is frost hardy.

Aloe ecklonis, like other aloes, is generally hardy but can be susceptible to certain diseases. The most common issues include: root rot, caused by poor drainage or overwatering, which manifests as soft stems and yellow leaves. Leaf spot, a fungal infection often due to high humidity, appears as brown or black spots on leaves. Aloe rust, another fungal disease, produces orange or brown pustules on leaves. Soft rot, a bacterial infection, results in water-soaked, mushy areas on leaves or stems. Pests such as mealybugs and scale insects are common pests that can weaken the plant and lead to secondary infections. Prevention involves ensuring proper drainage, avoiding overwatering, providing good air circulation, and using sterile tools when propagating or pruning. Treatment typically includes improving growing conditions, removing affected parts, and potentially using appropriate fungicides or insecticides.