Like many species of the Aloe genus, Aloe kniphofioides should be grown in a well drained soil. They thrive in a mixture of one third sandy soil, one third river sand or fine gravel and one third very well-rotted compost. Finely sieved peat moss can be used instead of compost. A. kniphofioides grow best in earthenware containers as they absorb any access moisture after irrigating. This plant should be grown in a position of morning sunlight or light dappled shade. In summer rainfall areas the plant can also be cultivated in a rockery provided that the position has deep soil and it is well drained, as it is the case in its natural habitat. In midwinter, late July or early August, dry veld grass should be heaped around the dead leaves of adult plants and ignited. It should be regularly watered afterwards. The burning usually stimulates flower bud formation a few weeks later.

The plant should be well watered throughout spring and summer. Watering should be reduced and the plants kept completely dry during the winter months.

Aloe kniphofioides rarely sets any seed in cultivation. It needs hand pollination while the plants are in flower. Seeds should be sown in the late spring. Scatter them on the soil surface of deep seed trays or earthenware pots and lightly cover with soil. The bottom of the container has to be filled with a coarse drainage medium. Seeds are sown in the same mixture used for propagation of adult plants. Soil should be kept moist throughout the germination period and for the remainder of the summer while the seedlings are developing. They should be kept dry and in a cool, shaded place for the duration of winter. Seedlings of Aloe kniphofioides are usually ready for transplanting at the beginning of the third growing season.