Aloe pretoriensis grows very well in cultivation and is suitable for rockeries and water-wise gardens, where the winter is cool with light frost or no frost, and also as a pot plant. It grows well in full sun and must be planted in a well-drained soil, on a slope. During hot weather, water once a week and twice a month in normal summer temperatures, and once a month in winter. When mature plants are removed from the soil, or are being transplanted into bigger pots, leave the plant out of the soil for 2 to 3 days to dry and cut off the old roots to prevent rotting of the root system and promote growth of new roots.

Aloe pretoriensis can be propagated using both sexual (seed sowing) and asexual (stem cutting) propagating methods. Sow seed during the warm months (mainly March and April) on coarse river sand and slightly cover the seeds with a layer of sand, not more than 2 mm deep, and keep the medium moist. Seeds germinate after 3 to 4 weeks. Transplant the seedlings 1 to 2 months after germination. Seedlings must be transplanted into a medium consisting of 2 parts coarse river sand and 1 part of well-rotted compost. Asexual propagation is done with leaf cuttings using a clean, sharp instrument. Allow the cut leaves to dry in a cool, airy place, away from direct sunlight for a few days, until the cut ends have dried and dust the wounds with a fungicide. Plants the leaf cuttings in a well-drained potting medium, in an area lightly shaded, cool and with high relative humidity. Keep moist but not wet.

Aloe pretoriensis is prone to gall mite (aloe cancer), white scale, aphids, rust and they can be controlled by a fungicide or pesticide application. Prevent plant infection by sterilising your medium, tools, only using disease-free seeds, and also monitor pest and control them at an early stage to prevent spreading. Remove plants infested with gall mite, as it is difficult to treat it.