Anacampseros filamentosa is adapted to an arid environment and they are slow growing. To grow this plant, it is recommended to use open, free-draining, mineral-rich, rocky or sandy soil, with minimal organic matter (such as peat or humus) added. Given the plant's susceptibility to rot, this type of soil allows the roots to breathe, leading to proper development of roots. Watering should be moderate, allowing the soil to dry up fully in between applications. This species prefers warm temperatures and should be protected from frost and cold breezes.

Anacampseros filamentosa can be propagated through germination of seeds, which can be sown in the spring. This could be done by adding well-draining soil to a seed germination tray, evenly distributing seeds over the surface and gently covering with a thin coating of soil mixture. The soil must be misted to keep it slightly damp, then placed it in an indirectly lit area with a temperature between 18 and 21°C. Germination usually takes one to three months.

Propagation by division can be achieved by separating offsets or pups from the main plant. It is recommended to wait a day to allow the divided stems to dry and form calluses over any cuts made during separation. The offset or pups should be planted in well-draining soil. This propagation method is advised to be done during warm temperatures in the spring season.

Stem cuttings can be used to propagate Anacampseros filamentosa during the summer. Cut a healthy stem from the parent plant, let it dry for a few days after cutting to promote the growth of callus. Place the cuttings in a container with gritty soil that drains properly. Give minimal watering until the cutting takes root.

The maintenance of the health of Anacampseros filamentosa subsp. filamentosa is essential, as proper exposure and ventilation will help prevent scarring, stunting, and even death of the plant. Plants are susceptible to pests, including red spider mites, mealybugs, and scale insects, as well as parasites. Red spider mites can be controlled by misting or watering the plants from above, while mealybugs can be treated by dabbing them with cotton swabs dipped in alcohol or soaking the succulent’s roots in a systemic insecticide. Cryptogamic diseases can be prevented with proper care, such as appropriate watering and air circulation, to avoid rot.