Different parts of the plant have various uses. Leaves, flowers, and fruits are edible. The leaves are used to treat smallpox, TB and yellow fever. The bark has been used to treat hernias and snakebite. The root is used traditionally to treat viral infections, gastritis, male sexual impotence, erectile dysfunction, dizziness and snake bites. In addition, the root also works well for infectious infections. It is also possible to treat chicken pox using the tree's juice. Malaria has been treated with Annona senegalensis in Guinea. The bark is also used in Eswatini to heal open wounds. The wood is soft and white, and is used for building huts and to make handles for utensils.

In Mozambique, children are fed the roots to promote forgetfulness of their mother’s milk. The roots can also be mixed with Trema orientalis to make a strong emetic. Flowers are used in cooking. Livestock feed on the leaves and humans eat the leaves as a vegetable. The fruit is edible with a pleasant pineapple-like aroma. Anonna senegalensis has also been used to manage pests in Tanzania and Nigeria. In the Republic of Benin, the fresh leaves are placed inside poultry buildings to dry out. By so doing, it will get rid of parasites like fleas and lice. This is done once or twice a week.