The soil needs to be well-drained sand with quartzitic gravel added. A loam-based garden soil mixed with sand and gravel is ideal. Seed should be sown during the autumn. Germination is within three weeks and the small plants can be transplanted after a year. Sow seed in shallow trays in a sandy mixture. Cover with a thin layer of sand (2 mm) and water by capillary action (place bottom of seed tray in a shallow bucket of water for a while, until sufficient water has been absorbed). Keep in a sunny corner. Water sufficiently during the first winter but keep dry during the summer. The young seedlings can be planted out after a year. Cuttings can be made from leaf pairs during autumn. Cut from as close to the base as possible. Allow to dry out for a week. Plant in sand and water well. Keep in a sunny corner. Rooting should take place within a month.

Outside of its habitat it is best grown in a glasshouse. Argyroderma theartii is best grown as a potplant. It also thrives in miniature gardens grown with companion plants such as Crassula and other dwarf mesembs such as Conophytum. It can be grown in rockeries only if the rainfall and climate allows it. Gardens within the karoo region or similar situations are ideal.

Soil should consist of gravel and sand with ample loam or clay. This plant needs a sunny site. Only water during autumn and winter and withhold water during summer months. Containers should be well drained. Place a gravel layer at base of container. Water sparingly during the cool months and a liquid organic fertilizer can occasionally be added. Plants can remain in the same container for a number of years. The plant skin should become wrinkly during this time but it is perfectly normal.

Pests include the caterpillar of the tiger moth. It is easily controlled by hand or spraying with a contact poison.