Barleria bremekampii can be propagated either by seed or cuttings.

Collect the seed as the capsules turn brown. Open the capsules and harvest the seed. Fertile seeds are well developed. Plant the seeds in a mixture of equal parts of coarse river sand, soil and compost from October to March. Place the container with seed in a shady spot and water once a week. Seed germination takes place after 6–10 days. Transplant the seedlings into containers when they are 100 mm in size.

Barleria bremekampi can be grown from cuttings, but it is difficult to do so. Take semi-hardwood cuttings, 120 mm in size, in summer, and treat the cuttings with a hormone powder to stimulate root growth. Use a mixture of even parts river sand and a bark potting mixture as a growing medium. Put the container in a shady place and water twice a week. Transplant the rooted cuttings after 3–4 months. Expect a success rate of 10%.

Barleria bremkampii is a water-wise plant and does well in sandy and loam soils.Use it in combination with other water-wise plants such as Portulacaria afra (spekboom), Aloe marlothii subsp. marlothii (mountain aloe) and A. chabaudii. To establish a hedge, plants should be planted 500 mm apart, in full sun, and pruned lightly every three months to stimulate new grow to form a firm hedge.