Barleria monticola can be propagated either by seed or cuttings.

To harvest the seeds, collect and open the ripe, brown fruit capsules. Fertile seeds are always well developed. Use an equal mixture of coarse river sand, soil and compost.  Plant the seed from October to January. Cover the planted seeds slightly with the growing mixture. Place the container with seed in a shady spot and water once a week. Seed germination takes place after 6–10 days. Transplant the seedlings into containers when they are 100 mm in size.

It is very difficult to grow Barleria monticola from cuttings because of the suffrutex (woody rootstock) of the plants. Take semi-hardwood cuttings in summer, 120 mm in size, and treat them with a hormone powder to stimulate root growth. Use coarse river sand as a growing medium. Put the container with cuttings in a shady place and water twice a week. Transplant the rooted cuttings after 3–4 months. Expect a success rate of 5%.

Barleria monticola does well as a groundcover in sunny Highveld gardens. Use it in combination with shrubs like Plumbago auriculata ‘alba’  and Tecoma capensis ‘lutea’ (Cape honeysuckle). No pests or diseases have been encountered.