Plants are easily grown from seed, stem cuttings or aerial tubers produced along the stems. Use equal parts of a soil-based potting mixture, coarse sand and perlite as growing medium. Make sure drainage is good. All propagation should be done in the time of active growth (summer).

Plants may be propagated easily from seed, if obtainable. Sow seed in spring in a seedling soil mix and cover with a few millimeters of fine sand. Keep moist, and seeds will germinate in about 1–2 weeks.

Aerial tubers can be used as anchor. Best is to use a tuber of ± 2 cm in diameter. Place the tuber on top of ± 2.5 cm coarse sand and perlite mixture to prevent rotting and cover with thin layer of fine sand. Place newly potted tubers or stem in medium light and water sparingly until feeder roots are established (to ± 8 weeks – in this time no aerial growth will be seen until the roots are well established).

Stem cuttings can be made by pruning some of the vine, to get stems with at least a couple of internodes. Place them in a container with water. Place the cuttings in a position of good light and moderate temperature and wait for roots to form from the stems or nodes. Roots should appear after a few days to weeks, depending on the light and temperature; after the cuttings have rooted, they can be potted.

Plants need ample light, at least 3–4 hours of direct sunlight a day, especially when indoors, less causes the stems to elongate and the leaves to lose their colouration so that they become homogenously green. Normal room temperature is suitable throughout the year. Water sparingly in the active growing period and only keep potting mixture moist, not wet or soggy; allow the top two thirds to dry out between watering. Reduce watering further in the dormant phase (winter), but still do not let the potting mixture dry out fully. A plant can grow for a couple of years in a pot or when more than one tuber is planted in a pot, space them 3.5–5.0 cm apart. It is the ideal hanging plant, with its heart-shaped leaves growing on thin vines.

Feed mature plants with liquid fertilizer once a month during the active growing season, but the concentration should be half of what is prescribed, in order not to burn the roots or tuber.

Rosary vines prefer warm temperature and bright light, but should not be placed in direct sunlight. When grown indoors, the optimum temperature is 25–30ºC in summer and preferably not below 15ºC in winter. String of hearts is an easy plant to grow and durable and an excellent house plant. It is regarded as a leaf-succulent vine.

This plant can be grown outdoors in tropical or subtropical climates, but is also an easy indoor plant that can be grown on a sunny window sill. In strong light the leaves will be darkly coloured, with distinctive marbling; if not given enough light they will be a light green colour. Houseplants could be moved outside in summer, but need to be acclimatized gradually to the stronger light, to prevent sunburn. If moved outside, be sure to bring indoors before the first frost. In winter, keep the plants in relatively warm conditions, above 15ºC. A minimum over-wintering temperature of 10ºC is adequate, providing the plants are kept relatively dry then.

Too much water can cause the thickened white roots of many Ceropegia species or the tubers such as those of Ceropegia linearis subsp. woodii not only to rot, but make them susceptible to woolly aphid infestation.