Cheiridopsis denticulata can be grown easily from seeds. Sow seeds in autumn, and, to improve the chances of germination, place the seeds in a small container with warm water for 24 hours. This will help to soften the hard outer layer of the seeds. Sow the seeds in a sandy medium and cover them with a thin layer of fine sand about 1 mm thick. Keep them damp, using a fine spray, until seeds start to germinate in about seven to fourteen days. Once the seedlings start growing, slowly reduce the amount of water.

C. denticulata normally grows in small, almost pure stands. It is characteristic of Namaqualand, which lies in the winter-rainfall region with hot, dry summers. It needs little water but responds well to regular watering in autumn to winter. It also needs a sandy, well-drained soil that is rich in minerals. Watering should be minimal in summer, but plants can be sprayed with a fine mist from time to time. They do well when grown in conditions similar to those in their natural habitat or in a greenhouse.