Coleonema aspalathoides is easy to grow and requires a sunny position with well-drained soil, enriched with well-decomposed compost (leaf mould). It will benefit from an annual mulching, which suppresses weed growth and keeps the soil temperature even, requires moderate watering and responds well to slow-release fertilizer like 3:1:5. Pinching of young growth and light pruning after flowering will encourage bushiness. Coleonema aspalathoides can be considered hardy to light frost (short periods down to -5 °C) but is not suitable for permanent outdoor cultivation in regions that experience prolonged periods at freezing temperatures.

Coleonema aspalathoides occurs naturally in mixed mountain fynbos and is ideally suited to the fynbos garden, grown with typical fynbos plants such as proteas, ericas, restios, pelargoniums, vygies and many other indigenous plants. It is also a good container plant, and is an interesting addition to the mixed border or the rockery. It is also useful as a filler for flower arranging.

Propagation is by seed or cuttings. Fresh seed should be sown in mid-autumn (April). Germination occurs in 4 to 6 weeks with an average success rate of 40%. Cuttings have the advantage of producing a larger plant that will reach flowering size sooner than seedlings. Tip cuttings, 50-70 mm long, should be taken from the current year's growth in spring (September). Prepare the cuttings by making a clean cut below the node and removing one third of the foliage. Dip the base of the cutting in a rooting hormone such as Seradix 2. Firmly place the cuttings in a medium of 50% bark and 50% polystyrene. Ideally these cuttings should now be placed in an well-aerated propagation unit with bottom heat of 24C and intermittent mist. Rooting occurs in 9 to 11 weeks and a weaning period of 2 weeks is recommended. Carefully pot the rooted cuttings into well-drained humus enriched potting medium (e.g. 2 parts leaf mould : 1 part coarse sand). Plants will be ready for planting into the garden in 7 to 8 months. Feed regularly but sparingly with a well-balanced fertilizer. Yellow leaves can be treated with an application of iron chelate.