Coleus hereroensis is an easy and reliable plant to propagate from both seeds and cuttings. Cuttings can be collected throughout the year, although spring and summer provide the best results. It is advisable to collect material early in the morning and prepare the cuttings under shade to prevent wilting. Softwood or semi-hardwood cuttings are most suitable. Each cutting should have at least two nodes, with the leaves removed from the lower node while retaining the top leaves. The cuttings should be inserted into clean river sand and kept consistently moist but not waterlogged. They must remain under shade or partial shade until rooting occurs, which usually begins around the third week. Once fully rooted, the young plants can be moved to a hardening-off area before transplanting. Although rooting hormone may be applied, it is not necessary and often not recommended for many Coleus species because it can cause stem rot.

Propagation can also be done from seed. Seeds should be sown in a well-drained soil mix and lightly covered with a fine-sieved medium. The trays should be placed in a warm, semi-shaded position away from direct sunlight. Germination generally begins within three weeks.

When planting in the garden, the soil should be well drained and enriched with plenty of compost. This is because the species has a shallow root system, organically rich soil supports healthy root development and growth. Mulch after planting as it helps to retain moisture and suppress weeds. Coleus hereroensis grows well in full sun and semi-shade, although flowering is more prolific in full sun. Despite its tolerance of sunny conditions, the plant does not store water in its stems, so regular watering is important during dry periods.

Pruning is essential to encourage bushy growth and the production of more flowering stems. This should be done at the end of winter before new growth begins in spring. The plant is tender to frost, but if frost damage occurs, it can be pruned back and will recover well. Flowering typically takes place in late summer and autumn, and pruning does not significantly affect blooming. After pruning, a layer of compost or organic mulch should be added to nourish the plant gradually and maintain soil moisture.

In landscaping, this species can be planted as a border or combined with other colourful plants. It pairs well with species such as Barleria albostellata or many other Barleria species, creating a striking colourful display in the garden.