It can be easily grown from cuttings. Plant it in a rich, well-composted garden soil that drains well. Water it regularly during hot and dry spells. Prune the plant after flowering to stimulate new growth and preserve its appearance. It is a low maintenance plant ideal for beginners or developed gardens and pests and diseases are generally not a major issue with this species.

When growing the species, one must be cautious when grouping it with other plants by making sure that it is grouped with plants of a similar growth habit as it tends to suppress other smaller and less robust plants.

The species is drought-resistant and should be planted with other drought-resistant species. Even though the species will survive frost when planted in a protected area, if not, in winter, it will be cut back to ground by frost and should be mulched to protect the roots, so the plant survives and resprouts in spring.

Coleus subspicatus does well in semi-shaded to sunny areas and will need more watering when grown in a sunnier position but one needs to be careful not to overwater it as leaves can be shed prematurely when overwatered. Remove the spent flower spikes regularly to extend flowering and prune lightly when they have finished flowering. The growing shoots can be pinched out regularly during summer season to promote more compact growth.

Avoid fertilizing while the plants are in flower. Apply a 2:3:2 or 3:1:5 granular or liquid fertilisers to feed the plant in spring and early summer, followed by proper watering, to avoid burning the tender roots.