Like many species of Combretum, seed propagation is successful when fruits are harvested at maturity, dried, and the seeds are removed from their winged coverings. Soaking the seeds in water for a few hours prior to sowing enhances germination. Sow seeds in spring to early summer in a well-drained sandy or loamy medium, keep moist and place in a warm, shaded environment. Germination typically begins within one to two weeks and is usually completed within three to four weeks under optimal conditions of moisture and warmth.

Vegetative propagation using semi-hardwood cuttings has also proven to be a reliable method, particularly when cuttings are treated with rooting hormones such as indole-3-butyric acid (IBA) and placed in a moist, well-aerated rooting medium such as a soil–sand or pine bark mix. Under high humidity conditions, rooting generally occurs within three to six weeks. In addition to conventional methods, tissue culture techniques such as micropropagation have been developed for other medicinally important Combretum species, indicating the potential for clonal propagation of C. afrum through in vitro approaches. These propagation strategies provide practical options for the cultivation, conservation, and sustainable use of this species.