Cotula sericea is one of the most rewarding and easy-to-grow plants. It can be grown from seed, but it is mostly grown from cuttings because it roots so easily without the need of rooting hormones or any special media. Cuttings can be made from young, but not soft, vigorous shoots from parent plants. Often, if these shoots are touching the soil, they will already have produced roots. The cuttings can be planted directly into the garden soil where they will root and grow without requiring anything other than frequent watering until they are well established. For those gardeners wishing to grow them first in pots or trays, semi-hardwood tip- and stem-cuttings can be taken during the warmer months. Place cuttings in a well-drained, light potting mix in an area that receives good light, but not direct sunlight. Water frequently until cuttings have established themselves. The propagation tray can also be placed in a clear plastic bag to increase the humidity, although the cuttings must then be watched carefully for mould or rotting if the potting mix becomes too wet and warm. Once the cuttings are established they can be used in pots or garden beds. Cotula sericea tolerates quite a wide range of soils but seems to thrive best in well-drained, humus-rich soils. In sandier well-drained soils, the silky cotula will require extra feeding and regular watering for enhanced growth.

Place Cotula sericea in full sun, although it will also do well in lightly shaded areas. This cotula is quite water-wise even though it prefers regular watering. Placed in the correct area this plant can go without water for quite some time. Drooping tips will indicate the need for more water and help indicate if the established watering regime for your specific environment is sufficient.

Few if any pests have been noticed on this plant. Young stems in very moist or wet conditions may be prone to fungal infection, but this is quite an infrequent problem usually related to mechanical damage sustained by the plant. Cotula sericea will tolerate and even welcome regular fertilizing. Chemical fertilizers must be applied at soil level as they may burn the soft leaves, and they should be washed off if accidentally applied incorrectly.

In hanging baskets or pots, the plants will need replenishing quite often to remain attractive. Young stems can be cut and replanted to form new displays.

In the garden the silky cotula can be planted as a mass ground cover or in the foreground with companion plants such as Selago canescens to make fantastic colour and textural contrasts. Use strong, smooth-foliaged accent plants, such as Dietes grandiflora and Agapanthus species as companions to highlight the soft silky appearance of Cotula sericea foliage. Combining the silky cotula with Monopsis unidentata or Geranium incanum makes a bold colour combination and compliments the yellow buttons well in a mixed groundcover border or pot display.