This is a plant that requires little or not much care. Cotyledon velutina is easily propagated by cuttings, and through seed that can be collected after it has finished flowering. However, growing Cotyledon velutina from seed is difficult and the seeds are difficult germinate. No pre-treatment of the seeds is required. Sow the seeds in a sandy sowing mix or in mineral-based cat litter or perlite, the seeds are very small and need to remain on the surface. The sown seeds should be kept moist but not wet, and watered once a week in winter and once a month in summer. The seeds will show signs of germination during the cool period of the year.

Take cuttings in the spring and autumn months. Prior to planting the cuttings, the wound needs to heal to prevent rotting, hence sulfur powder is applied on the wound. Plant the cuttings in a loose, aerated growing mix, such as a mixture of peatmoss, perlite, sand and vermiculite at a 4:2:2:2 ratio. These cuttings will start rooting and producing new buds within one to two weeks after it was propagated.

Plants are known to suffer from fungal infections when planted in areas that have high temperatures and moisture. These diseases lead to black spot and powdery mildew. Remove the affected parts and treat the plant using a recommended fungicide to prevent the infection spreading to other parts of the plant. Pests such as aphids, white flies, spider mites, may infest the plant during the summer season, sucking its sap. When they are found on the plant, the best way to control these pests is to either pick them off or wash them away using water, or apply a suitable pesticide if they are in large numbers.