Crassula alba is easy to grow, it thrives in well-drained, loam soil with a neutral ph. It prefers bright light with some direct sunlight and will have spindly growth with no flowers if it does not get enough light. Water often and fertilize every two weeks, with a balanced liquid fertilizer diluted by half, during the growing season, from spring to summer (September to April). Before watering again, allow the top layer of the soil to dry somewhat. Water sparingly while the plants are dormant during autumn and winter (May to August).

In a garden, Crassula alba is an ideal specimen for a sunny rockery or mixed succulent garden bed, and is a very popular choice for roof gardens, container plants, soil stabiliser and as a filler. These plants are useful ground covers because of their dwarf growth habit, the ease with which they establish themselves and their rapid growth rate.

Crassula alba can be easily propagated by seeds, stem cuttings, leaf cuttings or by basal offsets. Take cuttings or remove offsets in spring. Take 5 cm long stem cuttings and plant them in a soil mixture of equal parts of peat moss and sand, and keep it at normal room temperature in bright filtered light. The seeds are very fine and must be harvested as soon the flower turns brown and as the fruits ripen. Sow seeds in spring, in a mixture of river sand and potting mix. Avoid over watering to prevent damping off.

When a potted plant becomes root bound or the soil needs to be renewed, repot in the spring. Because these plants are noted for being top-heavy, it is best to use a nice solid and substantial pot. They will not tip over if they are in a heavy pot.

Crassula alba plants are susceptible to attack by two species of Lycaenidae butterfly, the Common Black Eye, Gonatomyrina gorgias gorgias and the Tailed Black Eye, Leptomyrina hirundo, which use them as larval host plants.