Crassula dependens is easy to propagate and suitable for beginners. Common methods include seed sowing, leaf and stem cuttings, and division. Seeds are tiny and best sown in early spring or late summer on well-drained sandy loam enriched with compost. Lightly cover seeds (about 3 mm) and keep moist in bright, indirect light; germination takes 14–20 days. For leaf cuttings, detach a healthy leaf and allow it to callus for 2–3 days. Place it in coarse sand or a sandy potting soil mix, keep the soil slightly moist, and provide indirect light. Roots appear within 2–3 weeks. Take stem cuttings, 8–10 cm long, also allow to callus for a few days before planting in the same mix; rooting hormone is not required. Water sparingly until established. Division suits mature mats—carefully separate rooted sections and replant in well-draining soil. Keep divided plants in partial shade for a week to reduce transplant shock.

Crassula dependens thrives in full sun to partial shade and is suitable for indoor containers or outdoor beds. Outdoors, morning sun with afternoon shade is ideal, especially in hot climates. It prefers well-draining sandy or loamy soils with a neutral to slightly acidic pH (6.0–7.5). Avoid heavy or waterlogged soils to prevent root rot. Water only when the soil is dry—about every 10–14 days in summer and less in winter. Overwatering causes yellowing and soft leaves; withhold water until recovery. Feed with a diluted succulent fertilizer every 4–6 weeks during the growing season. The plant tolerates light frost in sheltered spots but should be protected or moved indoors in areas with severe frost. It grows slowly and requires minimal pruning; pinching leggy stems encourages bushier growth.

It is ideal for rock gardens, hanging baskets, retaining walls, and as a trailing groundcover. Its fine stems soften edges and help control erosion on slopes. Pair with drought-tolerant succulents like Delosperma, Portulacaria or compact species of Aloe for textural contrast. It is not suited for lawns or formal hedges but fits well in informal, naturalistic plantings.

Crassula dependens is generally hardy but susceptible to fungal diseases such as leaf spot and root rot in wet or humid conditions. Ensure good drainage and air circulation, avoid overhead watering, and remove infected tissue promptly. Spider mites may infest dry indoor plants, causing yellowing and webbing. Control by increasing humidity, wiping leaves, or applying insecticidal soap. Maintain plant health by avoiding overwatering, removing dead leaves, and fertilizing lightly during the growing season.