Cyrtanthus obliquus is an evergreen species that grows in well-drained soils and has a well-defined dry period during winter (March-August). Bulbs should be planted in relatively small pots in a well-drained, humus-rich potting mixture and kept in full sun. Care must be taken not to overwater the plants, and regular feeding with a commercial plant food is recommended.

Plants can be multiplied by removing the side bulbs that develop from time to time. Side bulbs can also be induced by damaging the basal plate of the parent bulb and then growing it in coarse sand until the new bulbs develop. Pot them up once they have grown sufficient roots to maintain themselves.

Seeds can be used to generate large numbers of plants but, due to the slow growth rate, it will be at least 10 years before they mature and flower.

Sow seeds in a fairly deep seed tray in a well-drained, humus-rich potting mixture. Lightly cover the seed and keep it moist in a well-ventilated, shady area. Germination takes 3-4 weeks.

The Amaryllis lily borer is one of the few pests which attack the foliage during summer. It can be controlled by either removing the caterpillars by hand or by spraying with a synthetic pyrethroid-based insecticide.