Cyrtanthus sanguineus can be propagated by lifting a clump and separating the bulblets growing underground and planting them as new plants. This method should be conducted in spring, after flowering. The offsets need to be planted with the bulb necks exposed, immediately after separating them from the main bulb. Use an acid or neutral growing medium that drains well, such as equal parts of loam, finely sifted acid compost and coarse grit/river sand. After planting, water the plants by drenching the container then repeat once or twice per week, allowing the medium to dry out in between watering. Propagated plants must be placed in a well ventilated green house with enough sunlight, especially in the mornings.

It can also be propagated by seed, sown as soon as it is ripe, in deep seed trays using a sandy medium, planted just below the surface and well-spaced to avoid damping-off. Pot up into larger containers in their second season.

Plant the bulbs with the upper third exposed. The plants like to grow in crowded clumps, flowering best when in a crowd, and should be left undisturbed for many years. Place them in semi-shade, or light shade. Plants are half hardy and can withstand temperatures to 0°C.

Be on the lookout for lily borers, mealy bugs and snails, which attack both the leaves and bulbs of C. sanguineus.