Use Drosanthemum bicolor in the garden with other colourful mesembs (vygies). Plants die after some years and care should be taken to keep seedlings for replacement.

They grow easily from seed and cuttings. To speed up germination, allow the seeds to soak in hot water for a day before sowing. Do not boil the seeds in the water. Sow seeds in autumn or summer in a seed tray of river sand, scatter over a large area, as overcrowding of seeds will cause damping off. Care should be taken to sprinkle the sown area lightly with river sand. Place seed tray in a sunny position, keep the soil medium moist (use a mist sprayer) and after two weeks the seeds will germinate. Cuttings should be taken after fruiting, from midsummer to autumn (December to April in South Africa).

White scale is a pest on the plants. To control this use a horticultural oil-based product to smother these insects.