Dymondia margaretae makes a wonderful groundcover and can be used to good effect under plants such as cycads (Encephalartos spp.) by highlighting their strong focal point. It is often used as a filler between pavers and railway sleepers, a border for pathways or a lawn substitute in sunny courtyards. It is a valuable plant in coastal gardens, helping to limit wind erosion in bare patches and retain soil on slopes. In areas of high rainfall it should be grown on a generous slope or raised rockery to improve drainage. It will tolerate being grown in light dry shade, but dies back in large unsightly patches if overwatered. It is tolerant of light frost.

This wonderful plant can be grown from seed, cuttings or division. The most usual and easiest method of propagation is division followed by tip cuttings. Vegetative propagation is best done in late winter or early spring as the plant prepares for its new growth season. Tip cuttings can be made from shoots off the rhizomes and, with the aid of a rooting hormone, should root within 3-4 weeks. Place tip cuttings into well-drained sandy soil and keep moist but not wet.

Runners from mature stands can be dug up and removed with roots to be replanted. Replanting is best done the same day, as the runners' chance of surviving is lessened the longer they are without soil. Plant into sandy, well-drained soil and add a generous amount of well-rotted compost. Plant approximately 200 mm apart for quick cover. Water new plants well until settled, and then water only as required.

Stressed plants turn up their leaves revealing more of the fuzzy, whiter underside. An organic slow-release fertilizer can be used to keep plants growing vigorously and mature plantings can be divided every few years to retain vigour.