Fortunately, Encephalartos nubimontanus is relatively well represented in cycad collections around the world and can be easily propagated from seeds. Seeds are collected when they are red-orange in colour, cleaned by removing the outer coat using a table knife or by soaking them in water for 2 to 3 days and rubbing off the flesh. Then put them in a bucket filled with water to determine whether the seeds are fertile. The fertile seeds will sink to the bottom, whereas the infertile seeds will float on top. Seeds are sown on a bed of clean, coarse sand, with bottom heating of 25–28ºC, in a mist house with an automatic irrigation system. The seeds are pushed into the sand so that they are level with the surface of the sand. Sow seeds when they are fresh, at any time of the year. Another propagation method is to sow seeds under a tree where there is shade, a little bit of sunlight and lots of leaves. Place the seeds under the leaves and irrigate twice a week. After 2 months the seeds begin to germinate. The seedlings can be removed and potted after 10 months into 4 litre bags containing a mixture of compost and river sand, and placed in the nursery. This species can be planted out into the garden in summer, when the root ball is 2 cm wide.

Encephalartos nubimontanus can be also be propagated by removing offsets (suckers) in early spring. Remove them using a sharp, clean cutting tool. Apply fungicide to the cut area of the mother plant and the offset. Suckers with roots can be repotted immediately. Suckers with no roots should be left in a cool, dry area for a few weeks for the wound to form a callus, and then potted.

This species is a fast grower. It is hardy, drought resistant and responds very well in full sun or semi-shade, in well-drained soil, with sufficient moisture and in frost free conditions. It is suited to subtropical and warm temperate regions. Frost may burn the leaves but will not kill established plants. It prefers a sheltered position and wind is likely to damage the leaves.

When planting Encephalartos nubimontanus in the ground, dig a hole deep enough so that the soil around the base of the plant remains at its original level. To provide a good start for the plant, mix the soil with a little bit of slow-release, balanced fertilizer and bone meal. This species is naturally undemanding for nutrients. Spray the root ball with fungicide to reduce the risk of fungal infection and plant. Water the plant until soaked, once after planting, because it is adapted to a dry habitat. Too much water causes rot since this species likes its soil to dry out. Prune the leaves when they are completely dead, because it allows the plant to grow faster and fatter, whilst not easily noticed with the naked eye. This species can be planted anywhere since the roots are not aggressive. 

Encephalartos nubimontanus can be used in the garden as a focal point and it is suitable for containers.

Encephalartos nubimontanus is usually attacked by pests such as white scales and woolly aphids; pesticides are used to control them. Termites also attack the plant; insecticides are used to control them.