Euphorbia schinzii can be propagated through seeds or stem cuttings. To propagate from seeds, harvest mature seed capsules and sow them in well-draining soil. Maintaining consistent soil moisture until germination, typically occurring within a few weeks, is essential. Upon the emergence of seedlings, when several sets of true leaves have developed, they can be transplanted into individual pots. Propagation via stem cuttings involves taking a healthy stem segment with a sharp, sterilized knife, allowing it to form a callus by leaving it in a cool, dry place for a few days to prevent rotting, and planting it in a well-draining soil mix suitable for succulents. Soil should be kept lightly moist until roots develop, usually over a few weeks. Once roots are established, the cutting can be treated as a mature plant.

Euphorbia schinzii is well suited to warm, dry bushveld and grassland gardens and is ideal for rocky slopes. It needs well-drained loamy soil, plenty of well-rotted compost and moderate water in spring and summer and a dry winter without frost. Best in semi-shade. Also suitable for containers. Take care not to overwater.

When growing Euphorbia schinzii as a container plant indoors, it prefers a position in bright, indirect sunlight. Place it near a sunny window where it can receive several hours of sunlight per day. However, avoid intense, direct sunlight, as it can scorch the plant. This plant thrives in warm temperatures, and it needs to be protected from cold drafts and frost.