Ficus bubu is easily cultivated from seeds or cuttings. Collect seeds from mature fruits, clean them, and plant them in a well-drained soil such as sand or loam. Maintain moderate wetness until germination, which might take many weeks. Cuttings can be rooted in sandy soil through the use of a rooting hormone. A mist house can help speed up the rooting process, but it is not required. Spring is the ideal period for propagation. When seedlings or rooted cuttings reach a few centimeters in height, they should be carefully transplanted into separate pots and grown on for a period until hardened, prior to planting out in the garden.

This fig grows in well-drained soil, favouring loam or sandy loam having a pH ranging from slightly acid to neutral. It thrives in full sunlight to semi-shade and needs moderate watering throughout the establishing period however, once fully established, it becomes drought-tolerant. Mulching near the base conserves soil moisture and suppresses weeds. Fertilize annually with a balanced organic compost. It tolerates slight frost but must be sheltered in colder climates. Prune sparingly to shape and maintain a clean canopy.

Ficus bubu makes an excellent shade tree in big gardens, parks and naturalized areas. Its thick foliage makes it an ideal screening tree or focal point. Planting near pavement or buildings is not recommended owing to its powerful roots. It is not ideal for containers or limited areas, but it works well with companion plants such as Aloidendron barberae and Carissa macrocarpa, which require equal amounts of water and sunlight.

The tree is largely pest-resistant, however it may attract scale bugs or aphids, which may be managed using insecticidal soap. Fungal infections are uncommon, but can arise in excessively damp circumstances; appropriate spacing with well-drained soil reduce hazards. Its fruits might draw birds, assisting in natural seed dispersal.