The tongue-leaf plant is one of the easiest slow-growing succulent plants to cultivate and grow. Propagation can take place by means of seed and cuttings. It grows best in full sun, semi-shade or light shade and in temperatures ranging from 15°C to 35°C. A loam based, well-drained, composted soil mix is a good soil medium and will provide optimal results. Moderate water is needed from the middle of summer until end of winter. Plants need minimal water during spring and summer but water can be given when leaves start to shrivel.

The best method to produce Glottiphyllum depressum plants is from stem cuttings and seed sowing.

Seeds germinate very easily and can be sown in spring or early summer, from September to November or throughout the year in warm climates. Avoid seed sowing when the weather is extremely hot. Seed can be sown in a soil medium consisting of a sandy loam and placed where the temperature ranges between 20-25°C. Sow seed in a flat seed tray with adequate drainage holes at the bottom. Keep the sowing medium slightly damp, to prevent rot from overwatering. During periods of hot temperatures, inspect your seed once in the morning when temperatures are still cool and do not water when the soil is still damp. Do not sow the seed too deep under the soil medium as it will create difficulty for the seed too germinate. The ideal sowing depth is 2 mm.

Germination can take place with or without bottom heat. The use of bottom heat will allow seed to easily germinate as it provides an ideal humid environment. Seed germination can take place from 1 to 8 weeks. Seedlings can be pricked out when they are 3-5 cm high and planted in a succulent or cacti mix with good drainage. Seedlings need to be gradually hardened off before placing them in their permanent location. Place them under full sun or light shade and water moderately.

Glottiphyllum depressum can also be propagated by means of stem cuttings taken at the end of summer. Take cuttings from the stem of the plant and allow it to dry and form a callus before striking it in a well-drained soil mixture or coarse river sand. Root development takes place very easily and therefore no rooting hormone is needed. Place the cuttings in an area with a temperature ranging from 15-20°C. Water the soil every third day to prevent the soil from becoming waterlogged. Cuttings will develop roots within two to three weeks. Once transplanted, place it in a hardening off area with a temperature range of 15-21°C. For optimal growth, place young plants in full sun or light shade. Water moderately during the growing season.

The tongue-leaf can go for long periods without water, even when it is exposed to very dry temperatures. No fertilizer is needed when growing Glottiphyllum depressum, as the plant is adapted to grow in dry hot weather and still grow to its full potential. Glottiphyllum depressum forms a mat in the growth location and can therefore be planted in an area to stabilize the soil and prevent soil erosion.