Glottiphyllum regium seeds germinate very easily. Seed matures nearly five months after flowering. Once the seed capsule is dry (pale brown colour), seeds should be extracted as soon as possible otherwise they will soon be lost to the elements - rain. Mesemb capsules are hygrochastic, an intriguing mechanism whereby seeds are dispersed by raindrops. When it rains, the keels of the wet seed capsules push open valves. Raindrops hitting the open seed capsule splatter seeds in different directions, thus ensuring recruitment and the subsequent survival of the species. Seeds are round, light brown in colour and 1.0-1.5 mm in diameter.

Seed can be sown at most times of the year. Avoid very hot weather (Jan./Feb. - southern hemisphere). Sow the seeds in a flat seed pan. Ensure that there is adequate provision for drainage in the bottom of the seed pan. If the seeds stand in too much water, they will more than likely rot. The best medium to sow the seeds in is a sandy loam mixture. On top of this mixture, sprinkle a thin layer of coarse river sand, 2 mm deep. It is into this sand that the seeds are sown. Keep the area weed-free and water every second day. During very hot and dry weather water daily, preferably in the early morning when it is cool. Ensure, when watering, that the seeds are not blasted out of the soil; gentle watering is advised. Ensure that the seed trays are positioned in a sunny area - morning sun only. Seeds should be sown 2 mm below the soil surface. Do not sow the seeds too deep. If sown too deep, they will be smothered and probably not germinate. Under ideal conditions, seedlings will grow rapidly. Plant the seedlings out when they are 3-5 cm in height.

Glottiphyllum regium flourishes in well-drained, loam soils. It can be cultivated in pots or planted in groups in the garden. Remember to plant it in a sunny locality, otherwise it will not flower properly.

Glottiphyllum regium is perennial and may live as long as 30 years in its natural habitat. In cultivation they may live for only 15 years. The main problem is people tend to over-water them, shortening their life-span considerably. Glottiphyllum regium is drought-resistant and as such is ideal for waterwise, sunny courtyard or container gardens.

A word of warning - great care must be taken not to plant this species in heavy clay soils.

Glottiphyllum regium occurs naturally only in the winter rainfall areas, but can be cultivated successfully in the summer rainfall areas of South Africa.