G. denudata is best suited for planting in coastal and semi-coastal fynbos gardens as garden filler behind small shrubs and ground covers.   Space it at least 3 m apart when planting, since it has a tendency to overgrow other plants. In late winter, prune overlapping branches almost to the ground, or cut back for shaping at least every 2–3 years and expect it to resprout in mid-summer to autumn.

For increased growth, add an organic fertilizer. There have been no pests recorded that attack this plant, other than Phytophthora.

Gnidia denudata is best propagated from tip, stem and heel cuttings taken in summer. Use a root-stimulating hormone for semi-hardwood. The plant material must be taken from a healthy, vigorous mother stock, preferably at the coolest time of the day, to prevent water loss during cutting. Use a well-drained, rooting mixture of bark, silica grit, polystyrene or perlite, and water well. Place the cuttings on warm benches, in a moderate humid, misthouse. Rooting should take place after 5–6 weeks. Once cuttings have produced adequate roots, transplant into a slightly bigger pot. After 4–5 weeks, once well-established, transplant cuttings into larger containers and water regularly until they are fully grown. Established plants can be transplanted into bigger containers or out into the garden.