Many species of this genus are widely used medicinally in both African and European traditions. A European medical record states that the researchers have found that Helichrysum oils are a more effective anti-inflammatory than German chamomile, have more tissue regenerating properties than lavender, and are more cicatrisant (helping the formation of scar tissue) than frankincense.

The leaves of Helichrysum appendiculatum are a Xhosa remedy for chest troubles, and they are sometimes eaten raw for this purpose. The plant is also used by traditional healers for smallpox, and is said to be antihelminthic (preventing worm infestation).

The white, woolly lower surface of the leaf is stripped to make fringes and body ornaments.

Helichrysums are also used for decoration.  They have bright yellow, dull gold, pink, or silvery white flowers which are dried and used in flower pictures and for other purposes such as flower arrangements.