Jamesbrittenia kraussiana is best propagated and responds best when it is vegetatively propagated from tip and stem cuttings, preferably taken in summer (mid-October to mid-February), to allow better root growth. Use a root-stimulating hormone for soft cuttings; take cuttings from a healthy, disease-free, vigorous mother stock, preferably at the coolest time of the day (morning or afternoon), to prevent water loss during the process.

Prepare your propagation area by cleaning the surfaces and prepare your tools and equipment, such as secateurs, rooting hormone, seed tray and a propagation media mix of sifted fine bark, perlite and sand (2:1:1). Start by sterilizing your rooting medium mix and your cuttings with a sterilizing agent, add coarse bark at the bottom of the tray, to allow drainage. Take the cuttings below the node, each cutting about 6 to 7 cm long and remove the two-thirds of the bottom leaves to reduce loss of water through the leaves. Dip the cuttings in a rooting hormone; insert them in the rooting medium, and place the tray of cuttings in a warm area, about 20–25ºC with 80% relative humidity. Rooting should take place within 2 weeks. Harden off the rooted cuttings in a cool shaded area with a good flow of air.

Pot the rooted cuttings in 12 to 15 cm pots using a general potting mix of sifted bark and sand and compost (1:1:1). Place all the potted plants in semi-shade for 2 weeks and water well at least twice a week. Once the root system has developed fully, they are ready to be planted out into the garden. Choose a full sun to semi-shaded area and it is best to plant in the rainy season, autumn to winter time (May to August) in the Western Cape, to prevent excessive use of water. Prepare the soil in the garden by adding compost and organic fertilizer to encourage new growth, and mix and aerate the soil to encourage root establishment.

When grown in a controlled environment such as a glasshouse, it is susceptible to white fly, which can be combatted or controlled with the use of the yellow sticky trap, which they are attracted to.