Jamesbrittenia tysonii is relatively easy to propagate from cuttings if you select healthy parent plants. The cuttings should have at least 2-3 nodes. Propagation is done using semi-softwood cuttings or herbaceous cuttings.The rooting medium should be sterile and well-aerated, such as perlite + bark (1:1). Various commonly available rooting hormones were trialled to determine the most effective option for root development. The process began with pre-watering the media before planting the cuttings, followed by additional watering with a seaweed-based growth stimulant. The prepared cuttings were then placed in a mist house to maintain optimal humidity for successful rooting. The results showed a 100% germination rate across all trials and semi-softwood cuttings developed roots after two to three weeks. Cuttings can be taken from early spring.

Grow Jamesbrittenia tysonii in well-drained, composted soil, in a sunny position. Water moderately throughout the year. Prune when young to encourage branching but otherwise these plants do not require much pruning. Although frost hardiness has not been tested, judging by its natural habitat it should be able to withstand frost to -5°C. Plants are drought-tolerant when established. This plant does well at Kirstenbosch National Botanical Garden in Cape Town where it has been grown as a bedding plant, and is well-suited to Karoo, Grassland and Highveld gardens, and is suitable for containers.