Ledebouria confusa is a relatively easy subject for cultivation and can make a handsome pot subject or an interesting and curious addition to a succulent rockery. It can also be used to good effect as a companion plant to other succulent plants such as aloes. The species requires full sun and a warm to hot position, it prefers a 2 parts well-drained sandy loam soil mixed with one part compost; adding sifted kraal manure is beneficial. Watering in summer is best done in the form of infrequent heavy watering, during the dry winter dormant season it is best to allow the plants to dry out completely. This species can tolerate severe frost in winter provided it is kept dry. Since this species seldom produces any basal offsets, it is best to propagate them by seed.

Seed should be sown as soon as possible after harvesting, as they quickly loose viability with age. Sow the seed evenly on a firmly tamped surface in a pot or seed tray using a mixture of sandy loam and well decomposed and sifted compost, and cover by about 2 mm of the same sifted mixture or coarse sand. The seed trays should be kept damp for the first few weeks until most of the seeds have germinated, after which watering should be gradually reduced to reduce the incidence of fungal infection. Seedlings can be planted out into individual containers after one year of growth. Seedlings can attain adult sized flowering bulbs within three to four years under cultivation.