Ledebouria galpinii is very easy to maintain in cultivation. The species is best suited to containers in full sun or well-lit dappled shade, in a cool climate. The bulbs should be planted in a very sandy, mineral soil, with small amounts of sifted kraal (cattle) manure, well-aged compost and some peat added. Watering should be generous in the summer growing period, and is best completely withheld in the dry winter dormancy.

In their natural habitat, the species would receive abundant moisture from soaking rain and condensation from frequent mist.

They prefer a cool climate where summer temperatures seldom go above 25ºC, and can withstand very cold temperatures in winter when the soil is usually almost completely dry and the plants are dormant. During the dry winter dormancy period, the pots should be moved out of the rain and placed in a dry, cool area with good air movement. Watering can commence at the onset of warmer weather (August to September).

Propagation from seed is the best method of producing new plants. Seed must be sown fresh (cannot be stored), in spring or summer in seed trays or pots filled with the sifted potting mixture detailed above. The seed can be sown on a firmly tamped surface and lightly covered with the same mixture, approximately 2 mm deep. The seed trays should be kept in a bright position out of direct sunlight and kept damp for between 2 to 3 weeks, until germination has commenced. The seedlings can remain in the seedling tray for many years because of their small adult size, or be planted out at the beginning of their second or third growing season. Flowering size bulbs can be attained after 1 or 2 years. Unusual for the genus, this species can also be propagated from leaf cuttings taken in the summer months.