Ledebouria luteola can be easily cultivated in pots or in the garden using an organic rich, loam soil with good drainage. The addition of sifted kraal (cattle) manure, bone meal and coarse sand, is beneficial. Plants prefer a warm summer climate with adequate watering in summer. During the dormant winter period, plants should be kept completely dry. Growing the plants in full sun will ensure the darkest and most pronounced leaf markings. During the dry winter dormancy period the pots should be moved out of the rain and placed in a dry, cool area with good air movement. Watering can commence at the onset of warmer weather (September to October in South Africa), by which time the plants have usually already commenced flowering.

Propagation from seed is the best method of producing more plants. Seed must be sown fresh. Sow the seeds in spring or summer, in seed trays filled with a sifted organic loam, with some sifted manure and sand added to facilitate good drainage. The seed can be sown on a firmly tamped surface and lightly covered with the same mixture approximately 3 mm deep. The trays should be kept in a bright, warm position out of direct sunlight and kept damp for between 2 to 3 weeks, until germination has commenced. Once the seedlings have emerged, watering can be reduced. The seedlings can remain in the seedling tray for one year and planted out at the beginning of their second growing season. Flowering size bulbs can be attained after 3 to 4 years. Tremendous variation in leaf size, shape and markings occurs in the natural populations of this species, therefore selection of the most attractive forms for cultivation, will be beneficial.