Ledebouria remifolia is easy to maintain in cultivation.I it is most suited to being grown in containers because of its small size and prefers an acidic peaty loam soil. An ideal potting mixture would include 1 part peat (or peat alternative such as palm peat or bagasse), 1 part old, well-rotted compost or sifted cattle manure and 1 part sandy loam. The potting medium should provide a slightly acidic soil environment. Watering should be frequent during the summer months, preferably using rainwater if available. The bulbs prefer a cool, summer climate, with good air circulation, and the soil should be kept moist throughout the growing season. Growing the plants in full sun, ensures a compact growth habit and intensifies the red colouration of the leaves and leaf stalks. During the dry winter dormancy period, the pots should be moved out of the rain and placed in a dry, cool area, with adequate air movement. During the dry winter months, the plants can be very lightly watered once a month, to maintain moisture content in the soil. Watering can commence towards the end of winter at the onset of warmer weather (August–September in South Africa).

Propagation from seed is the best method of producing more plants; the seed must be sown fresh. Sow seeds immediately (do not store them) in spring or summer, in shallow seed trays filled with the sifted potting mixture mentioned above. Sow seed on a firmly tamped surface and lightly cover with the same mixture approximately 1 mm deep. The trays should be kept in a bright position out of direct sunlight and kept damp until germination has commenced. Seedlings can remain in the seedling tray or be planted out as soon as they are large enough to handle. Flowering size bulbs can be attained after 1 to 2 years from germination.