Ledebouria sandersonii is not difficult to maintain in cultivation and makes a rewarding container plant. The plants prefer a cool climate, such as that found at higher altitudes and enjoys plenty of water,especially during the active growth period in summer. The species enjoys a humus-rich clay loam or loam soil, with some compost and kraal (cattle) manure added. Summer rains are frequent in the range of this species and it often grows in seepages in grassland where it is wet all summer long. During the cold, dry dormant season in winter, the pots are best kept almost dry, with a light watering occasionally, to prevent complete desiccation.

The best way to propagate this species is from seed, sown as fresh as possible and not stored for prolonged periods. Sow the seed in a sifted loamy soil, as mentioned above, in pots or trays on a firmly tamped surface. Cover the seed with about 3–5 mm of the sifted mixture and keep constantly damp, until all the seeds have germinated. Seedlings can be pricked out or left in their natal container for the first year to establish sizable bulbs. This species can reach flowering size in 2 to 3 years from seed.