Leysera tenella grows best in full sun with minimal semi-shaded spaces, in sandy to sandy-loam soils with good drainage.  It is best reproduced from seeds.

The seeds can be collected in summer and planted in seed sowing trays in the nursery or directly to the ground in autumn. Even though seeds of Leysera gnaphalodes have been recorded to be successfully germinated in spring, L. tenella has shows successful recruitment after being sown in autumn directly in the soil during restoration work done at Tygerberg Nature Reserve in 2022. This species adapts easily in the wild and does not require a specialist horticultural knowledge to be reproduced  from seeds. It is also not fussy about soil and one can use available varieties of seed sowing mixes, as long as they can provide good drainage and aeration to avoid suffocating germinated seeds with moisture. Soil mixes can even be made from home, containing sand and suitable organic growth media (well-composted compost, peat or fine bark). Ideally, the soil mixture should be fine and mixed in a ratio of 60% sand and 40% organic matter. Sow seeds on top of the germination mix and cover with a thin layer of fine soil particles. Immediately water the seed trays or the garden area where seeds are sown, using fine sprayer or mist sprayer to avoid washing off seeds, but allow them get attached to the soil surface. This species germinates and emerges successfully in  full sun. Seeds will also germinate under light shade, which is best when grown in the nursery where the seedlings are transplanted into a sunny bed when they are large enough to handle. Water the seeds at average intervals, there is no need to water frequently but for best results, the grower should not allow the soil to dry out completely during the germination phase. Germination and emergence of seedlings may be observed from 2 to 3 weeks after sowing seeds.

There are no records of little tortoise-tea or its relative species being reproduced by cuttings in national botanical gardens and there is also limited information on how to propagate this species vegetatively. Though, standard propagation protocols to reproduce most herbaceous and semi-hardwood species may be followed to propagate the little tortoise-tea by cuttings. The grower should ensure that the mother plant used to collect cuttings from is healthy and still in active growth for the best chance of a successful outcome. Collect tip cuttings in the morning, in autumn. Select or mix a cuttings growth medium containing 70% washed river sand and 30% potting soil or a sifted compost and then plant the cuttings into a shallow germination tray to allow good drainage. Cuttings can be kept inside the controlled greenhouse at a warm temperature, or in the mist house with heated benches and intermittent mist.

Growing and cultivating the little tortoise-tea should be one of the easiest things about the plant, as it grows naturally easy and is also found to be adapting easily in different environments. It is very effective and decorative when mass planted in sunny, open spaces. Where this plant is grown in  home gardens outside of its natural range, care should be taken to prevent it becoming a troublesome weed, because it seeds itself freely and widely, and germinates and establishes itself easily. Where the little tortoise-tea can be limited to a certain space in the garden, the plant can be effectively used as a pretty ornamental, to provide colour from its foliage and flowers.