This annual can be used a groundcover and covers quite a large amount of space, but it should be always pruned once it reaches a desired size, as it can dominate the area when not maintained well. No species are recorded as particular associates for M. crystallinum because of its wide tolerance and occurrence in a number of vegetation types. The associated species which are recorded on specimen labels in the Australian National Herbarium, include chenopods Muehlenbeckia sp., Acacia spp., Zygophyllum spp. and Eucalyptus largiflorens.

These plants are best cultivated in full sun positions. The young plants need water but older plants require little to no watering, as the roots restrict the consumption of water once the plant has accumulated enough water.

This plant can only be propagated by seed. To propagate it, mix equal amount of compost, peat moss or sand and vermiculite or perlite. Sift the material to remove any debris or small rocks. Place the medium in sowing trays, level and water it. Sow seeds and apply a thin layer of the medium on top, to cover the seeds, water again and place the trays in a warm area, where they will receive at least 10 hours of filtered light a day. Mist the pots as often as needed to encourage germination, thereafter the seeds will begin sprouting in about 14–21 days, depending on conditions. You can directly transplant the seedlings into a full sun area in your garden as soon as the seedlings are up to 2–3 cm tall. The plants must be watered upon transplanting, until the plants have fully developed into the soil.