Although the genus consists of many easily cultivated species, Cyrtanthus leucanthus is amongst those that are considered difficult or impossible to grow, being one of the deciduous species which must be kept absolutely dry once the leaves have fallen. They all require a very well-drained sandy medium containing varying amounts of organic matter, depending on their germination capability. As C. leucanthus is considered to be a difficult species to grow, even more sand and more gravel should be incorporated into its growing medium.

Due to fire being a requirement for blooming in the wild, it is a shy or slow bloomer in cultivation and more research is needed to find out whether treating it with smoke will trigger its flowering. As many bulbs of the genus are situated above the ground or the neck of the bulb grows level or just below the ground, the watering procedure is an important consideration. The more difficult deciduous species like C. leucanthus should be allowed to dry out completely between waterings during the growing period and should be kept absolutely dry when the plant has naturally stopped growing and the leaves have fallen off.