Diastella proteoides is mostly propagated from heel or tip cuttings taken in spring or autumn. The cuttings are treated with a rooting hormone used for encouraging root development of semi-hardwood cuttings. Cuttings are placed in shallow trays or preferably compartmentalised propagation trays and placed on heated benches and under mist or fog. A typical rooting medium would include equal parts milled pine bark and polystyrene pellets. Rooting is not as easy as with pincushions, but between 30 - 50% success has been achieved. Rooted cuttings are planted and grown in a sandy well-drained acid, potting medium. Regular feeding with an organic seaweed based fertiliser is recommended.

This plant has seldom been grown from seed, as it is very time consuming to collect the seed. If seed were sown it should be dusted with a fungicide to counter pre-emergence damping off and sown in late summer or autumn.

Diastella proteiodes has proved difficult to grow and sustain in a healthy condition at Kirstenbosch. This is probably because it prefers drier conditions than are the norm in the nursery or the gardens. The plant suffers from a wide range of fungal infections and therefore the cost of keeping it healthy through intervention with fungicides is prohibitive. Ex situ conservation in nurseries is therefore not a viable and sustainable option.