Lithops plants are easily cultivated from seed and also grown by means of cuttings. Seeds are produced annually in November and December (southern hemisphere). The seed must be completely dry. Normally the seed capsules are pale brown in colour when they are ripe. To extract the seed, merely break open the seed capsule with your fingers. The fine seed can be decanted into a small envelope.

For best results sow the seed in a well-drained substrate: coarse sieved river sand (1 mm in diameter) can be used. It is not necessary to cover the seed: the seeds are very fine and any topping or layer of soil over the seeds is likely to hamper their development. Just keep the substrate moist to stop germinating seedlings from drying out.

The ideal time to sow the lithops seeds is during the months of March, April or May in South Africa, when seeds would germinate in the wild, especially of those species from the western parts of South Africa. The seeds germinate relatively quickly. In just under a year they are ready for transplanting: use a well-drained substrate to plant the young seedlings in. One may also decorate around the plants with quartzite stones, thus enhancing their natural appearance. Water young seedlings four times a week during hot weather. A watering of once a week during winter should suffice. Whilst the seed is germinating, use a very fine mister when watering. Any spray head that produces large water droplets will wash the seed away.

Lithops can be grown from cuttings. One must be very careful to remove all dead tissue away from the base (root). Strike the cuttings during warm weather in coarse sand. The ideal time for preparing the cuttings is in March, April, September or October. Under warm conditions the cuttings root quickly.