The Transvaal red milkwood is easily cultivated and best utilized in larger gardens and open spaces. They may be used as individual specimen trees or groupings of several specimens where space permits. It is the ideal tree under which to create an entertainment area due to its wide canopy and dense shade created by the evergreen leaves. However, while the tree is in fruit it may not be ideally suited for this purpose as the birds and other animals may create a mess under the tree. It is well suited to cultivation in the medium to lower altitude regions of the summer rainfall areas of southern Africa and in protected valleys of the highveld areas. It is a popular bonsai subject and may also be attractive as an indoor plant, it is said to have a root system which is safe for planting near swimming pools, buildings and paving (Venter & Venter 1996).

The seed should be extracted from the fleshy fruit and sown fresh for best results. Seed have a high viability and germination begins within two weeks of sowing. The seedlings may be left in the seedling trays until the following spring or pricked out at the two-leaf stage into individual containers.

Growth rate of seedlings is fast and saplings of a metre or more can be obtained within three to four years of sowing. Rapid development under nursery conditions can be promoted by the use of balanced horticultural fertilizers. During this time the plants should be promoted to progressively larger containers to prevent root bounding.

Saplings are usually ready to be planted out after four or more years from sowing, at which time attention should be given to the planting hole. Mix good compost with the back filling soil and add bone meal or tree planting tablets to the bottom of the hole. Saplings can be watered well for the first year, gradually reducing irrigation over the ensuing two to three years to ensure the development of a deep root system.

In higher lying areas young trees should be protected against frost for the first three years while the tree becomes acclimatized and attains some height to offer more resistance to mild or moderate frost; this species will not survive any extreme degree of frost.

Mimusops zeyherii is not prone to disease, but may attract scale insects on the young stems and growth tips, which should be monitored on smaller specimens to ensure the damage is not unsustainable. If it becomes necessary, they may be sprayed with a product registered for use on scale. Mineral oil can be effective and is harmless to the ladybird beetles and spiders as well as the environment, in extremely stubborn cases mineral oil can be alternated with products containing chlorpyrifos at 750g/kg.

The trees may attract caterpillars at certain times of the year which should be left alone as they will pupate into beautiful butterflies and the damage they do to the tree will quickly be replaced with new growth. If such damage occurs on young saplings, caterpillars can be removed by hand or by using a strong spray of water.