Despite its scarcity in the wild, Moraea loubseri responds well to cultivation. The plants are most suitably grown in deep pots with a diameter of 25 cm, and a well drained acid or alkaline growing medium can be used. In the Kirstenbosch Bulb Nursery it is grown in a mixture of equal parts of coarse industrial (silica) sand and finely milled bark, with a 30 mm layer of well-rotted compost placed at the base of the container over the drainage chips. Mature corms are planted 20 mm deep in autumn. An initial heavy drench is provided in mid-autumn, followed by twice-weekly applications once the leaves appear and thereafter throughout the winter growing period. It is important to maintain sufficient moisture during flower bud formation to prevent plants from entering dormancy prematurely. Similarly, the plants require heavy drenching during the flowering and fruiting periods in order to perform optimally.

The plants respond well to liquid or slow-release fertilizer applications with high potassium but low nitrogen content. Once the leaves start turning yellow in early summer, watering must cease until the following autumn. The plants are not suited to general garden cultivation owing to their need for a completely dry summer, and due to the corms falling prey to mole rats and porcupines; in areas not plagued by these animals, they can be grown in dedicated rock garden pockets kept dry in summer. M. loubseri is half-hardy and able to withstand temperatures down to 0°C for short periods, but in cold winter climates it needs to be grown in the cool greenhouse. When maintaining a large bulb collection, it is important to harvest the ripe capsules of M. loubseri in time, immediately after they have started to split, as the seeds are released in gusts of wind and readily colonise adjacent pots.

The corms are fairly long-lived, lasting about 8-10 years under ideal conditions. To obtain pure seed, it is necessary to isolate and hand-pollinate the flowers. Pollen can be collected by dabbing a water paint brush over the ripe anthers, which are located directly beneath the style branches. Pollen is ready for collection once it has turned bright orange and become somewhat sticky. Then, moving to a flower of a different clone, lightly brush the two stigma 'flaps' situated just above the top of each anther. Seed sets readily after successful fertilization and 50 seeds or more can be harvested from a single capsule. Seeds are sown in autumn in the same medium recommended for adult corms. Fresh seeds germinate readily within 3 weeks and, in ideal conditions, flowering can occur in the second year, but more usually this takes place in the third spring season. Excellent viability of fresh seeds is maintained when stored at room temperature for 6 months following harvesting and sowing in the immediately ensuing autumn, but viability decreases markedly thereafter. Long-term storage of seeds is excellent at 6-7°C, and this can easily be achieved by the home-grower using the vegetable compartment of a fridge. This species can also be propagated by separation of corm offsets in early autumn.

The leaves, stems, flower buds and developing capsules are susceptible to attack by aphids, and the leaf undersides to red spider mites as temperatures rise in spring.