Stayneria neilii is best suited for well-drained rockeries in combination with Aloe microstigma , the speckled Worcester Aloe, the showy Drosanthemum speciosum with its masses of red flowers , the handsome cushion-like Cylindrophyllum tugwelliae with their solitary large white flowers and Cotyledon orbiculata with yellow flowers. Plants are easily propagated from seeds or cuttings but seeds are preferred as they produce better genetic variability. Seeds can be sown in autumn in a sandy loam soil. Keep the seeds moist by misting. Plants will only start to flower when they reach a height of about 70 cm. Cuttings can be taken in autumn, and no rooting hormone powder is necessary. Cuttings are planted in well-drained coarse river sand. The genus is prone to attack by white scale insects and red spider mite. (S. Hammer, pers. comm. 2013).

It is important to keep the plants dry in summer as this will reduce the chance of fungal or white scale infestation.