Zantedeschia odorata adapts well to cultivation and is easily grown outdoors in temperate climates in rock garden pockets, raised beds and deep containers. Although it occurs in seasonally wet doleritic clay in the wild, this is not a requirement in cultivation, as long as it receives sufficient moisture from autumn to late spring. It requires a position in full sun and grows well in loam soils containing plenty of well-decomposed organic matter. Plant the tuberous stems in groups 5 – 8 cm deep in autumn, and water well. Once the leaf shoots appear, water well twice per week until the end of the flowering period. Unlike Z. aethiopica whose rootstocks are not adversely affected by moisture during the dormant period, it is most important that Z. odorata rootstocks are given a completely dry rest for the full duration of summer to prevent fungal rotting.

Propagation is best from seed as the plants do not readily form offsets. Sow seeds 5 mm deep in deep seed trays in autumn in a well-drained medium such as equal parts coarse river sand and finely milled bark or potting compost. Keep the sowing medium moist by watering with a fine rose, and fresh seeds will germinate within two to three weeks. At the beginning of their second autumn, pot them up into plastic nursery bags or pots and allow them to grow on for one year. At the beginning of their third autumn, place them in permanent containers, raised beds or deep containers. Flowers can be expected in the third year, if grown well.

The rootstocks require protection from porcupines, especially during the active growth and flowering periods.