Cotyledon tomentosa subsp. ladismithiensis is easily grown in rockeries, water-wise gardens and containers. It grows well in well-drained soil in full sun, but can also grow in semi-shaded areas. It is commonly attacked by aphids on the young shoots and inflorescence, but this is easily controlled by a pesticide application.

it is easily propagated by stem cuttings. Fill the seed tray with coarse bark at the bottom of the tray (to improve drainage) and river sand on top as a medium. Make sure that the trays and secateurs are sterilized. Take cuttings about 15 cm long and remove some of the leaves (at least 2 or 3 leaves per cutting); and use a rooting hormone. Cuttings must be placed in a warm spot with the temperature between 22 to 27 degrees Centigrade, with a good relative humidity, and the medium must be kept moist.

To grow from seed, sow seed in April ( autumn). Fill the seed tray with coarse bark at the bottom of the tray (to improve drainage) and river sand on the top as medium, and water before sowing. Scatter seeds evenly. Do not cover the seeds; place them in a warm spot and keep the medium moist. Water from the bottom by placing seedtray in a shallow container which can be filled with water or use fine spray (mist spray) to prevent disturbing and washing the seeds away. Seeds start to germinate from 3–4 week after sowing and take 8 to 10 months to reach a size for transplanting.